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Gas Chromatographic Separation of Saturated Aliphatic Hydrocarbon Enantiomers on Permethylated ß-Cyclodextrin
Uwe J. Meierhenrich
(1)*, Mai-Julie Nguyen (2), Bernard Barbier (2),
André Brack (2), and Wolfram H.-P. Thiemann (1)
(1) Bremen University,
Dept. Physical Chemistry, Germany
(2) Centre de
Biophysique Moléculaire, Orléans, France
Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryostat controlled gas chromatograph is described. The use of a cryogenic system allows the improvement of separations for various chiral aliphatic hydrocarbons. The molecular cyclodextrin based mechanism of the achieved enantiomeric separations is discussed briefly. Possible applications of this analytical technique are summarized with special emphasis on the planned enantiomeric separation experiment on a cometary nucleus.
Chirality 15 (2003), S13-S16
This article
was cited in:
Meierhenrich UJ, Thiemann WHP: Photochemical concepts on the origin of
biomolecular
asymmetry. Orig. Life Evol.
Biosphere 34 (2004), 111-121.
Last updated September 2003